Systemic Amoxicillin Plus Metronidazole in Peri-implantitis Treatment
Status:
Completed
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
The primary objective of this controlled clinical trial is to evaluate the clinical effect of
systemic amoxicillin plus metronidazole therapy in conjunction with initial non-surgical
treatment of peri-implantitis. The secondary objective is to assess the microbiological
effectiveness of this peri-implantitis treatment approach.
The present study is a single-blind, randomized controlled clinical trial. Adult patients
with at least one endosseous implant in the oral cavity with clinical and radiographical
evidence of periimplantitis will be included in this study.
Patients with implants affected by peri-implantitis will receive initial periodontal
treatment existing of oral hygiene instructions and mechanical cleansing of both implants and
remaining dentition. Immediately after initial periodontal therapy patients will be
instructed to rinse their mouth with 0.12% chlorhexidine + 0.05% cetylpyridinium chloride
without alcohol twice daily during 30 seconds for 2 weeks. Additionally patients will receive
a recipe for medication consisting of 500 mg amoxicillin and 500 mg metronidazole to be taken
every 8 hours for the following 7 days or no recipe.
The main study parameter is the mean peri-implant bleeding score.