Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Status:
Withdrawn
Trial end date:
2018-04-01
Target enrollment:
Participant gender:
Summary
Oral corticosteroids are commonly utilized for the management of chronic rhinosinusitis with
and without nasal polyps (CRSwNP and CRSsNP, respectively). Although strong evidence supports
the benefit of routine and perioperative oral corticosteroids for CRSwNP, there is limited
evidence to support their utility for CRSsNP. The investigators intend to perform a
randomized, double blind, placebo controlled clinical trial to investigate the impact of
steroids used within 2 weeks prior to surgery for CRSsNP. Patients with CRSsNP that present
to the investigators office will be included if they have failed maximal medical management
and have elected to undergo endoscopic sinus surgery (ESS) after July 1, 2014. The
investigators hypothesis is that oral corticosteroids given 2 weeks prior to surgery will
improve subjective and objective outcome measures.