Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
The risk of dental fluorosis development is related to the systemic exposure to fluoride
during enamel formation. Currently, diet and fluoride toothpastes are the main sources of
fluoride to children at the age-risk for fluorosis development. However, when estimating the
risk of fluorosis from toothpaste inadvertently ingested, it has not been considered the
systemic fluoride bioavailability. Since some toothpaste formulations may contain part of
fluoride as insoluble salts, the hypothesis behind this study is that only soluble fluoride
in toothpastes would be absorbed when they are inadvertently ingested. To test that, adult
volunteers will ingest a standardized dose of total fluoride from commercially available
toothpastes, which present different concentrations of soluble fluoride. Fluoride systemic
bioavailability will be assessed by the release of fluoride in saliva up to 3 hours after
ingestion (as an indicator of blood fluoride) and by urinary fluoride excretion.