Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis

• Status: Completed
• Trial end date: 2009-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to test whether atorvastatin (also known as Lipitor) has anti-inflammatory effects in people with no known heart disease or high cholesterol. We also are investigating whether or not genetic differences between people plays a role in the drug response.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Florida
• Collaborators: American College of Clinical Pharmacy; American Heart Association
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• 18+ years old

• Normocholesterolemic

Exclusion Criteria:

• Cardiovascular disease or risk equivalents

• Malignancy

• Active alcohol abuse

• Contraindications to statins

• Interacting drugs

• Chronic anti-inflammatory drugs