Systemic Steroids for Peripheral Nerve Blocks

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will investigate the ability of systemic dexamethasone to prolong the sensory block duration for lumbar plexus nerve blockade.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Treatments: Anesthetics; BB 1101; Bupivacaine; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Epinephrine; Epinephryl borate; Racepinephrine

Criteria

Inclusion Criteria: Primary elective total hip arthroplasty surgery

• must be a candidate for placement of a lumbar plexus block under anatomic landmark technique using electrical stimulation

• must give written informed consent for anesthesia

• must also be reliable and able to give accurate verbal pain scores postoperatively

Exclusion Criteria:

• contraindications to regional anesthesia including, allergy to amide local anesthetics, presence of peripheral neurologic dysfunction, pre-existing coagulopathy or infection in the area of interest will be excluded.

• insulin and non-insulin dependent diabetes mellitus

• preoperative use of systemic corticosteroids within 30 days of surgery

• chronic opioid use (defined as daily opioid dose of greater than 40 mg of oxycodone equivalents or any long-acting opioid)

• pregnancy

• failure to effectively place the lumbar plexus block.

• known prior adverse reaction to dexamethasone (for example: psychosis) or an allergy to dexamethasone