Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics
Status:
Completed
Trial end date:
2017-05-26
Target enrollment:
Participant gender:
Summary
The purpose of the study is to better understand how the use of antibiotics changes
micro-organisms in the intestines. The change to micro-organisms in the intestines may change
the body's vaccine immune response and alter the effectiveness of the IIV (seasonal flu)
vaccine.
In particular, the investigators will be looking at certain markers in blood after
vaccination with IIV (seasonal flu vaccine) with or without the use of antibiotics before
vaccination.
There will be two randomized groups. Group A will start taking antibiotic by mouth 3 days
prior to vaccination and continue taking antibiotics the day of vaccination and one day after
vaccination for a total of 5 days. Group B will only receive the IIV (seasonal flu vaccine)
and will not take any antibiotics.
The investigators hope to enroll 50 subjects at Emory.