Systolic Hypertension in the Elderly Program (SHEP)

• Status: Completed
• Trial end date: 1996-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective was to assess whether long-term administration of antihypertensive therapy to elderly subjects with isolated systolic hypertension reduced the combined incidence of fatal and non-fatal stroke. The secondary objectives were to evaluate: the effect of long-term antihypertensive therapy on mortality from any cause in elderly people with isolated systolic hypertension; possible adverse effects of chronic use of antihypertensive drug treatment in this population; the effect of therapy on indices of quality-of-life; the natural history of isolated systolic hypertension in the placebo population.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
• Collaborator: National Institute on Aging (NIA)
• Treatments: Atenolol; Chlorthalidone; Reserpine

Criteria

Men and women, aged 60 or over, with isolated systolic hypertension.