T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Status:
Recruiting
Trial end date:
2025-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate what effect, if any, mismatched unrelated volunteer
donor and/or haploidentical related donor stem cell transplant may have on severe sickle cell
disease and other transfusion dependent anemias. By using mismatched unrelated volunteer
donor and/or haploidentical related donor stem cells, this study will increase the number of
patients who can undergo a stem cell transplant for their specified disease. Additionally,
using a T-cell depleted approach should reduce the incidence of graft-versus-host disease
which would otherwise be increased in a mismatched transplant setting.