TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

• Status: Not yet recruiting
• Trial end date: 2027-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to test a drug known as DFMO in people with Type 1 Diabetes (T1D). The main question[s] it aims to answer are:

• Does it reduce stress on the cells that make insulin?

• Does it preserve what is left of the body's insulin production? Participants will take either DFMO or a placebo (looks like DFMO but has no active ingredients) two times a day for about 6 months. Participants will have 6 in person visits and 1 phone visit over a period of 12 months. Visits will include blood draws urine collection and other tests.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Emily K. Sims
• Collaborators: Cancer Prevention Pharmaceuticals, Inc.; Juvenile Diabetes Research Foundation
• Treatments: Eflornithine

Criteria

Inclusion Criteria:

1. Males and females 6- ≥40 years of age with a clinical diagnosis of T1D

2. T1D clinical diagnosis with insulin start date no more than 100 days prior to the time of randomization

3. Random non-fasting C-peptide level of >0.2 pmol/mL (equivalent to >0.6ng/ml) at screening.

4. Positive for any one of the following diabetes-related autoantibodies (IAA, GAA, IA-2, or ZnT8)

5. Treatment naïve of any immunomodulatory agent

6. Normal hearing at screening, defined as acceptable results of pure-tone audiometry (<20 decibel [dB] baseline thresholds for frequencies 250, 500, 1000, and 2000 Hz

Exclusion Criteria:

1. Presence of severe, active disease that interferes with dietary intake or requires the use of chronic medication, with the exception of well-controlled hypothyroidism and mild asthma not requiring oral steroids. Presence of any psychiatric disorder that will affect ability to participate in study.

2. Diabetes other than T1D

3. Chronic illness known to affect glucose metabolism (e.g. Cushing syndrome, polycystic ovarian disorder, cystic fibrosis) or taking medications that affect glucose metabolism (e.g. steroids, metformin)

4. Inability to swallow pills

5. Psychiatric impairment or current use of anti-psychotic medication

6. Any condition that, in the investigator's opinion, may compromise study participation or may confound the interpretation of the study results.

7. Hematologic abnormalities at screening (anemia, leukopenia (particularly neutropenia), or thrombocytopenia)

8. Impaired renal function (assessed by history and BUN/Creatinine, DFMO is renally excreted)

9. Allergy to milk or soy (components of Boost® drink used for mixed meal tolerance testing)

10. Female participants of child-bearing age with reproductive potential, must not be pregnant and agree to use 2 effective forms of birth control or be abstinent during the study period (see below)

11. Active seizure disorder, defined as requiring chronic medication at the time of study or having had a seizure within the past 12 months at the time of screening