TELSTAR: Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation

• Status: Active, not recruiting
• Trial end date: 2022-01-24
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to estimate the effect of medical treatment of electro-encephalographic status epilepticus on neurological outcome of patients with postanoxic encephalopathy after cardiac arrest.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Twente
• Collaborators: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Maasstad Hospital; Medisch Spectrum Twente; Radboud University; Rijnstate Hospital; St. Antonius Hospital; Université Libre de Bruxelles; University Medical Center Groningen; VieCuri Medical Centre
• Treatments: Anticonvulsants; Etiracetam; Levetiracetam; Lorazepam; Midazolam; Propofol; Thiopental; Valproic Acid

Criteria

Inclusion Criteria:

• Patients after cardiac arrest with suspected postanoxic encephalopathy

• Age 18 years or older

• Continuous EEG with at least eight electrodes started within 24 hours after cardiac arrest

• Electroencephalographic status epilepticus on continuous EEG

• Possibility to start treatment within three hours after detection of electroencephalographic status epilepticus.

Exclusion Criteria:

• A known history of another medical condition with limited life expectancy (<6 months)

• Any progressive brain illness, such as a brain tumor or neurodegenerative disease

• Pre-admission Glasgow Outcome Scale score of 3 or lower

• Reason other than neurological condition to withdraw treatment

• Follow-up impossible due to logistic reasons