TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma

• Status: Completed
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Less intensive therapy may attain in the same results as intensive therapy in children with non-Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to study the effectiveness of less intensive therapy for children who have non-Hodgkin's lymphoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Oncology Group
• Collaborators: Children's Cancer and Leukaemia Group; National Cancer Institute (NCI); Societe Francaise Oncologie Pediatrique
• Treatments: Cortisol succinate; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate; Liposomal doxorubicin; Methotrexate; Prednisolone; Prednisone; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• One of the following diagnoses:

• Newly diagnosed B-cell non-Hodgkin's lymphoma in Revised European-American Lymphoma (REAL) categories II 9, 10, and 11, i.e.:

• Diffuse large cell

• Burkitt's

• High-grade B-cell, Burkitt's-like

• L3 leukemia with greater than 5% blasts in bone marrow

• No anaplastic large cell Ki1-positive lymphomas

• Immunophenotype and Murphy stage required prior to randomization

PATIENT CHARACTERISTICS:

Age:

• Over 6 months to under 21 years

• Maximum age 18 years in France and the United Kingdom

Other:

• No congenital immunodeficiency

• No prior organ transplantation

• No prior malignancy

• Not HIV positive

• Available for at least 36 months of follow-up

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy

Endocrine therapy:

• Steroids initiated no more than 72 hours prior to entry allowed

• Bone marrow and cerebrospinal fluid examination required prior to steroids

Radiotherapy:

• Emergency radiotherapy initiated no more than 72 hours prior to entry allowed

Surgery:

• Not specified