TNF-alfa Inhibitors and Antibody Production in Patients With Psoriasis
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
TNF alfa blockers are widely used for treatment of severe psoriasis. These biologics are
well-tolerated with few side effects.
Unfortunately not all patients respond adequately to treatment with tnf alfa blockers. Some
do not respond at all while others respond initially but gradually lose effect despite
increased dose and more frequent administration.
The cause of treatment failure is largely unknown and it may be production of tnf-alfa
neutralizing antibodies. This has been demonstrated in patients with rheumatoid arthritis and
inflammatory bowel disease who lost response after treatment with tnf-alfa blockers.