TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset
Status:
Recruiting
Trial end date:
2023-07-30
Target enrollment:
Participant gender:
Summary
Gulf War Illness is a condition that affects multiple major organ systems, resulting in a
diverse array of symptoms that include debilitating fatigue, memory and cognition
difficulties, headaches, sleep disturbances, gastrointestinal problems, skin rashes, and
musculoskeletal/joint pain. This phase I single-site, open-label two-arm study will assess
the safety and mechanistic efficacy of a sequential etanercept-mifepristone intervention for
Gulf War Illness. The results of this phase I study will be compared to those from an
existing short-duration study to identify the optimal duration and dosage for use in a future
phase II study.