TPI Medication Comparison - Ketorolac, Lidocaine, or Dexamethasone

• Status: Terminated
• Trial end date: 2019-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypothesis

The main hypothesis of this study is that anti-inflammatory medications (ketorolac or dexamethasone) will provide longer-lasting and greater pain relief than just lidocaine in trigger point injections where a local twitch response is evoked at the time of the injection.

Purpose/Specific Aims

The primary objective of this study is to compare the efficacy of three substances used in TPIs with a LTR identified at the time of the injection: a CS (dexamethasone), a NSAID (ketorolac), or only a local anesthetic (lidocaine).

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Utah
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Ketorolac; Ketorolac Tromethamine; Lidocaine

Criteria

Inclusion Criteria:

1. Men or women age 18 or over

2. At least one active trigger point

Exclusion Criteria:

1. Allergy or contraindication to any NSAID, CS, or local anesthetic

2. Receiving anticoagulant medication

3. History of bleeding disorder

4. Pregnant or breast feeding women

5. Gastrointestinal ulceration

6. Pre-existing renal disease

7. Pre-existing congestive heart failure

8. Diabetes mellitus

9. Prior myocardial infarction or stroke

10. Fibromyalgia