TRAUMA HELP: Healing and Analgesia With Propranolol

• Status: Withdrawn
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of North Carolina, Chapel Hill
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• at least one fracture

• ages 18-60 yrs

• pain score >= 4

• speak and read English

Exclusion Criteria:

• gunshot, stab wound, or assault

• paraplegia/quadriplegia

• pregnancy

• psychotic, suicidal, or homicidal

• hepatic, kidney failure

• clinically unstable or intubated at time of recruitment

• hyperthyroidism

• propranolol use within the last 6 months

• significant bradycardia

• cancer (except basal cell)

• peripheral vascular disease

• heart block > 1 degree

• breastfeeding

• congestive heart failure