TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA
Status:
Recruiting
Trial end date:
2023-12-30
Target enrollment:
Participant gender:
Summary
Several randomized, controlled trials, mostly involving women undergoing cesarean delivery,
have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after
childbirth reduced blood loss. Most were small, single-centre trials with considerable
methodologic limitations.
It is important to emphasize that none of these RCTs has included women at increased risk of
PPH such as placenta previa, a context in which the prevalence of moderate and severe blood
loss is significantly higher and where the magnitude of the effect of TXA may highly differ
compared to low risk women