Our previous results suggested that activation of peripheral TRPM8 expressed in the derma
tissue of limbs with sufficient concentration of menthol is beneficial to stroke recovery.
In the present study, sixty patients with acute ischemic stroke were randomly divided into
two groups: thirty in the treatment group and thirty in the control group. The treatment
group will use an emulsion containing 8% w/w menthol, with an average of 80 grams placed
inside hand and foot wraps (20 grams in each hand or foot wrap). The control group, on the
other hand, will use an emulsion that does not contain any menthol, with an average of 80
grams placed inside hand and foot wraps. Participants in this study will initially undergo a
detailed regular neurological examination, an assessment with the National Institutes of
Health Stroke Scale (NIHSS), Barthel Index (BI) for daily living functions, and the Modified
Rankin Scale (mRS) for disability. All participants will be re-evaluated after the fourth and
eighth weeks of the trial, with assessments including neurological examination, NIHSS, BI,
and mRS.
Phase:
Phase 4
Details
Lead Sponsor:
Taipei Medical University Hospital
Collaborators:
China Medical University, Taiwan Chung Shan Medical University