Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to compare efficacy and safety of two different immunosuppressive
regimens for prevention of bronchiolitis obliterans syndrome (BOS) (chronic lung allograft
rejection)after lung transplantation: tacrolimus versus cyclosporine, both in combination
with mycophenolate mofetil and steroids. The study was powered to detect a 15% reduction in
BOS in tacrolimus treated patients.
Study design: open-label, randomized, comparative, multi-center, investigator driven