Tadalafil Effects in Left Ventricle Diastolic Dysfunction in Resistant Hypertensive Patients
Status:
Completed
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
Left ventricle diastolic dysfunction (LVDD) is associated with resistant hypertension. In
addition, brain natriuretic peptide (BNP) levels are elevated when LVDD is present. It has
been shown that phosphodiesterase-5 (PDE5) inhibition improves left ventricle diastolic
function in hypertensive rats, despite any difference in blood pressure levels. Also, left
ventricle diastolic function enhancement reduces BNP concentration in hypertensive patients.
However, it is unknown if these effects exists in humans with resistant hypertension.
Therefore, this study was developed to evaluate if the use of a PDE5 inhibitor (tadalafil)
for 2 weeks improves LVDD and its effects in BNP levels in resistant hypertensive patients.
Phase:
N/A
Details
Lead Sponsor:
University of Campinas, Brazil
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo