Tailored Ovarian Stimulation Based on BMI, AMH, AFC

• Status: Recruiting
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The study objective is to develop a tailored based strategy for ovarian stimulation in IVF patients using AMH, BMI, antral follicle count (AFC).

300 patients will be randomized in 2 arms:

1. control group: standard care rec FSH.

2. study group: modified dose of Rec FSH based on AFC with a correction factor based on BMI and basal AMH level.

Primary endpoints: number of mature follicles and eggs collected at egg retrieval; amount of rec FSH used.

Secondary endpoints: fertilization rate; cleavage rate; clinical pregnancy rate; inhibin B and AMH levels during ovarian stimulation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Criteria

Inclusion Criteria:

• female infertile patients eligible for IVF treatment

Exclusion Criteria:

• polycystic ovaries

• untreated thyroid pathology

• hypogonadotropic hypogonadism

• untreaed hyperprolactinemia

• study drug hypersensitivity

• previous OHSS

• unilateral ovariectomy

• genital malformation

• BMI>40