Previous researchers indicate that impaired cognitive flexibility was the primary factor
distinguishing patients with from those without tardive dyskinesia (TD)1, and cognitive
dysfunction correlates positively with the severity of TD2. Longitudinal data raised the
possibility that the association between cognitive dysfunction and TD may reflect not organic
vulnerability to but rather a state marker for this movement disorder as "tardive dementia"3.
Atypical antipsychotic had been reported to alleviate the severity of TD4 and improved
neurocognitive function separately5. But no researchers ever investigated the correlation of
the two effects simultaneously. This randomized, single-blind and controlled study compared
the effect of atypical antipsychotic on TD, neurocognitive function and associated factors
for these changes.