Target Site Pharmacokinetics of Doripenem After a Single Dose of 500mg in Healthy Volunteers Dori_MD_1
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
In the present study we will measure and compare the unbound, i.e. microbiologically active
concentrations of doripenem after a single dose of 500mg in plasma, subcutaneous adipose
tissue and muscle tissue and saliva of healthy volunteers. We will use the microdialysis
technique, which allows for the continuous measurement of unbound drug concentrations in the
interstitial space fluid. The findings of the present study will help to assess whether
currently employed therapy regimens with doripenem provide effective antimicrobial
concentrations in different compartments in man