Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic

• Status: Completed
• Trial end date: 2018-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study assesses the effectiveness of targeted active case detection among high-risk populations in Southern Lao Peoples Democratic Republic (PDR). The investigators hypothesize that active case detection using the next generation of HRP-2 rapid diagnostic tests (RDTs) can help bridge gaps in identification of high-risk asymptomatic individuals with low density parasitemia, allowing for targeting of this reservoir and thereby reducing transmission. The investigators hypothesize that active case detection (testing and treating positive cases) with these RDTs will lead to a reduction in P. falciparum transmission.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Francisco
• Collaborators: Center for Malariology, Parasitology, and Entomology; Health Poverty Action; The National Institute of Public Health
• Treatments: Artemether; Artemether-lumefantrine combination; Artemether, Lumefantrine Drug Combination; Artemisinins; Lumefantrine; Primaquine

Criteria

Village Based MTAT

Inclusion Criteria

• All household members 18 months of age and older.

• Study participants include those in the 14 selected health center catchment areas within the four target districts in Champasak Province, Southern Lao PDR; Moulapamook, Panthampone, Sanamsaboun, and Soukhuma.

• Members of households who have provided informed consent will be included for blood samples collection and treatment for identified malaria cases if meeting the appropriate criteria.

Exclusion Criteria

• Household members less than 18 months of age will be excluded.

• Any individuals under the age of 18 months will be excluded from RDT testing and blood collection.

Peer Naviagtor-Led FTAT

Inclusion Criteria

• All persons 15 years and older who have spent at least one night outside a formal village in the past one month.

• Individuals must be 18 years and older and willing and able to provide consent to be included in the peer navigator or study staff focus group discussions and key informant interviews

• Study participants include those in the 14 selected health center catchment areas within the four target districts in Champasak Province, Southern Lao PDR; Moulapamook, Panthampone, Sanamsaboun, and Soukhuma

• High-risk populations in forested areas, rice field regions, plantations and any informal settlements

• Individuals travelling into the HCCA who are willing and sufficiently able to communicate with PNs to assess their eligibility

Exclusion criteria

• Individuals under the age of 18 will be excluded from peer navigator or study staff focus group discussions and key informant interviews.