Targeting ER Stress in Vascular Dysfunction

• Status: Recruiting
• Trial end date: 2022-08-30
• Target enrollment: 0
• Participant gender: All

Summary

Aging and obesity are both risk factors for cardiovascular disease (CVD). One process that links both of these conditions to CVD is vascular dysfunction. Data from animal studies indicate that endoplasmic reticulum (ER) stress may play an important role in the development of endothelial dysfunction in aging and obesity. Therefore, the goal of this study is to investigate the relative contributions of aging and obesity on vascular dysfunction and ER stress. Additionally, this study will determine if taking an oral supplement for 8 weeks will improve vascular dysfunction and ER stress. Results from this study have the potential to identify a safe treatment option for improving vascular function in aging and obese populations.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colorado State University
• Treatments: Acetylcholine; Ascorbic Acid; Nitroprusside

Criteria

Inclusion Criteria:

• Young, healthy weight adults (age: 18-35; BMI 18.5-24.9 kg/m2)

• Young, obese adults (age: 18-35; BMI 30- 39.9 kg/m2)

• Older, healthy weight adults (age: 60-80; 18.5-24.9 kg/m2)

• Older, obese adults (age: 60-80; 30-39.9 kg/m2)

Exclusion Criteria:

• blood pressure >140/90 mmHg

• triglycerides >500 mg/dL or LDL cholesterol >190 mg/dL

• current smoking or history of smoking in the last 12 months

• diagnosed chronic disease including cancer, cardiovascular, diabetes, kidney, liver, and pancreatic disease

• weight change >3 kg in the past 3 months or actively trying to lose weight

• >12 alcoholic drinks/week

• hormone replacement therapy