Aging and obesity are both risk factors for cardiovascular disease (CVD). One process that
links both of these conditions to CVD is vascular dysfunction. Data from animal studies
indicate that endoplasmic reticulum (ER) stress may play an important role in the development
of endothelial dysfunction in aging and obesity. Therefore, the goal of this study is to
investigate the relative contributions of aging and obesity on vascular dysfunction and ER
stress. Additionally, this study will determine if taking an oral supplement for 8 weeks will
improve vascular dysfunction and ER stress. Results from this study have the potential to
identify a safe treatment option for improving vascular function in aging and obese
populations.