Tazarotene 0.1% Cream For the Treatment of Cutaneous T-Cell Lymphoma: A Prospective Study

• Status: Unknown status
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is an open label, prospective study to evaluate therapeutic potential of Tazarotene 0.1% cream for the treatment of Stage I-IIA CTCL. Patients with Stage I-IIA disease are enrolled into the study. Tazarotene will be used for up to 24 weeks and patients will be followed for up to 12 months.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McGill University
• Treatments: Nicotinic Acids; Tazarotene

Criteria

Inclusion Criteria:

• Patients with Stage I-IIA CTCL must be at least 18 years of age with a skin biopsy prior to enrolment confirming the diagnosis of mycosis fungoides.

Exclusion Criteria:

• Patients with Stage >IIA CTCL at the time of enrolment

• Women who are pregnant or planning to get pregnant, or unable/unwilling to use adequate contraception

• Patients who were treated with topical retinoid therapy in the past 3 months

• Patients who received any systemic CTCL therapy or systemic corticosteroid therapy within 30 days of the study start date

• Patients who were treated with systemic isotretinoin or bexarotene within 3 months prior to the study start date, systemic acitretin within 2 years prior to study start date