Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining more than one drug may kill more tumor cells. It is not
yet known which regimen of chemotherapy is more effective in treating recurrent malignant
glioma.
PURPOSE: Randomized phase III trial to compare the effectiveness of temozolomide alone to
that of procarbazine, lomustine, and vincristine in treating patients who have recurrent
malignant glioma.