Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma
Status:
Terminated
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
This phase I trial studies the side effects and best dose of ascorbic acid when given
together with temozolomide in treating patients with high-grade glioma that has come back.
Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth
of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping
them from spreading. Ascorbic acid contains ingredients that may prevent or slow the growth
of high-grade gliomas. Giving temozolomide with ascorbic acid may kill more tumor cells.