Temozolomide and Bevacizumab in Treating Patients With Metastatic Melanoma of the Eye

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving temozolomide together with bevacizumab may kill more tumor cells.

PURPOSE: This phase II trial is studying giving temozolomide together with bevacizumab to see how well they work in treating patients with metastatic melanoma of the eye.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institut Curie
• Treatments: Bevacizumab; Dacarbazine; Temozolomide

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed uveal melanoma

• Metastatic disease

• Measurable disease, defined as ≥ 1 measurable lesion as measured by RECIST criteria

• No curative surgical treatment envisaged

• No active brain metastases (if clinical suspicion, must have a brain CT scan within 28 days)

PATIENT CHARACTERISTICS:

• WHO performance status (PS) 0-1 OR Karnofsky PS 70-100%

• Life expectancy ≥ 12 weeks

• Hemoglobin ≥ 10 g/dL

• Absolute neutrophil count ≥ 1,500/mm^3

• Platelet count ≥ 100,000/mm^3

• Serum creatinine ≤ 1.5 times upper limit of normal (ULN) OR calculated creatinine clearance ≥ 50 mL/min

• Proteinuria < 2+ on urinary dipstick OR 24-hour proteinuria ≤ 1 g

• Total bilirubin ≤ 1.5 times ULN

• AST/ALT ≤ 2.5 times ULN

• Lactate dehydrogenase ≤ 5 times ULN

• INR and PT ≤ 1.5 times ULN

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 6 months after completion of study treatment

• No uncontrolled active disease or at risk of bleeding, ongoing infection, or clotting disorder

• No other cancer except for skin carcinomas and cervical carcinoma in situ

• No pre-existing peripheral neuropathy, > grade 2 (NCI CTC-AE)

• No failure to comply with the medical follow-up of the study for geographical, social, or psychological reasons

• No recent thrombophlebitis or pulmonary embolism within the past 6 months

• No uncontrolled hypertension (systolic BP > 150 mm Hg and/or diastolic BP > 100 mm Hg)

• No concurrent active cardiovascular disease, uncontrolled by medical treatment within the past 6 months, including any of the following:

• Unstable angina

• Severe hypertension

• Severe arrhythmia

• No unhealed wound, active peptic ulcer, bone fracture, history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months

• No known hypersensitivity to bevacizumab, temozolomide, or their excipients

PRIOR CONCURRENT THERAPY:

• No prior chemotherapy for metastatic disease

• At least 24 hours since insertion of central infusion port

• More than 5 days since prior non-hepatic biopsy or aspiration cytology

• More than 10 days since prior aspirin (> 325 mg/day), clopidogrel (> 75 mg/day), or full-dose oral or parenteral anticoagulant therapy, except prophylactic anticoagulant therapy prior to inclusion in the study

• More than 14 days since prior laparoscopic liver biopsy

• More than 28 days since prior major surgery

• More than 28 days since prior participation in another study with experimental treatment

• No other concurrent anticancer treatment