Overview
Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System
Status:
Terminated
Terminated
Trial end date:
2010-03-01
2010-03-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
RATIONALE: Drugs used in chemotherapy, such as temozolomide, use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining temozolomide with radiation therapy may make the tumor cells more sensitive to radiation therapy and kill more tumor cells. PURPOSE: This phase II trial is studying how well giving temozolomide together with radiation therapy works in treating patients with stage IV malignant melanoma with measurable and unresectable cancer limited to the central nervous system.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Alliance for Clinical Trials in OncologyCollaborator:
National Cancer Institute (NCI)Treatments:
Dacarbazine
Temozolomide
Criteria
DISEASE CHARACTERISTICS:- Histologically confirmed stage IV malignant melanoma with measurable and unresectable
disease limited to the central nervous system (CNS)
- Study entry within 14 days of diagnosis of brain metastases
- Recursive partitioning analysis class I or II
- Disease for which no known standard therapy exists that is potentially curative or
proven capable of extending life expectancy
- No meningeal carcinomatosis based on imaging studies or on positive results from CSF
analysis
- No evidence of metastatic disease outside of the CNS
PATIENT CHARACTERISTICS:
Age
- 18 and over
Performance status
- Karnofsky 70-100%
Hematopoietic
- Absolute neutrophil count at least 1,500/mm^3
- Platelet count at least 100,000/mm^3
- Hemoglobin at least 9.0 g/dL
Hepatic
- AST no greater than 3 times upper limit of normal (ULN)
- Alkaline phosphatase no greater than 3 times ULN
Renal
- Creatinine no greater than 1.5 times ULN
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No concurrent uncontrolled infection
- No other malignancy within the past 5 years except basal cell or squamous cell skin
cancer treated with local resection only
- No prior allergy or intolerance to dacarbazine
- No hypersensitivity to temozolomide or any of its components
PRIOR CONCURRENT THERAPY:
Biologic therapy
- More than 4 weeks since prior biologic therapy
- More than 4 weeks since prior immunotherapy
Chemotherapy
- No prior temozolomide
- More than 4 weeks since prior chemotherapy (6 weeks for mitomycin or nitrosoureas) and
recovered
Endocrine therapy
- Concurrent steroids allowed if dose stable for at least 7 days prior to CNS imaging
Radiotherapy
- More than 4 weeks since prior radiotherapy
- No prior radiotherapy to more than 15% of the bone marrow
- No prior radiotherapy to the head and neck area
- No prior radiosurgery