Terlipressin in Septic Shock: Effects on Microcirculation

• Status: Completed
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study was conducted as a prospective, randomized study to investigate the effects of vasopressin receptor agonists terlipressin and vasopressin on systemic hemodynamics and microcirculation in patients with catecholamine-dependent septic shock.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Roma La Sapienza
• Treatments: Arginine Vasopressin; Lypressin; Terlipressin; Vasopressins

Criteria

Inclusion Criteria:

• Clinical diagnosis of septic shock

• Vasopressor support to maintain mean arterial pressure (MAP) between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 13-18 mmHg and central venous pressure = 8-12 mmHg)

Exclusion Criteria:

• Pregnancy

• Age < 18 years

• Present or suspected acute mesenteric ischemia

• Vasospastic diathesis (e.g. Raynaud's syndrome or related diseases)