Testicular Function After Iodine 131 Therapy in Papillary Carcinoma Patients
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
Papillary cancer may affect patients of any age,with a good prognosis. Most of young patients
may hence procreate as often as the general population.131iodine is an essential tool during
treatment of thyroid cancer. According literature data, 131iodine given patients may
experience exocrine testicular dysfunction with transient azoospermia, as a significant
growing number of Desoxyribonucleic acid (DNA) damage may concern the patient or his
offspring. The primary purpose will be to study a genomic instability within the germinal
line, based on a significant mutation rate analysis in their minisatellites regions after 100
mCi 131 iodine irradiation compared to the baseline spermogram of each patient, thus being
his own control case in a cross-over study.The inclusion of 50 patients treated by surgery
prior to131iodine would result in statistically significant results.This multicentric
cross-over study with a multidisciplinary approach will act for a direct benefit on testis
function in patients aged 18-45 treated by 131iodine for thyroid cancer. Samples measurements
timing will be: after surgery, 2 and 12 months after 131iodine administration.