Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty

• Status: Not yet recruiting
• Trial end date: 2026-06-30
• Target enrollment: 0
• Participant gender: All

Summary

To assess postoperative patient-reported quality of recovery after total knee arthroplasty (TKA) with periarticular joint injection (PAI) ± single shot adductor canal block with or without adductor canal catheter infusion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McMaster University
• Treatments: Ropivacaine

Criteria

Inclusion Criteria:

• All adult patients presenting for a primary TKA.

Exclusion Criteria:

• Age <18 years;

• Body mass index ≥45 kg/m2;

• Weight <80 kg;

• Deemed unsuitable for regional anesthesia;

• Planned general anesthesia;

• Hepatic insufficiency/Intolerance to acetaminophen;

• Renal insufficiency (defined by estimated glomerular filtration rate <60 mL/min/1.73 m2);

• Chronic opioid use (individuals requiring the equivalent of 1 mg or more of intravenous morphine, or 3 mg or more of oral morphine per hour for greater than 1 month);

• Allergy or intolerance to study medications (listed under 'Spinal and Adductor Canal Block') or trial medications listed in "Postoperative" section and "standard prescription"

• Clinical Frailty Scale score ≥4;