Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma
Status:
Not yet recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
This phase I trial tests the safety, side effects, and best dose of nivolumab in combination
with ASTX727 in treating B-cell lymphoma that has come back (relapsed) or does not response
to treatment (refractory). Immunotherapy with monoclonal antibodies, such as nivolumab, may
help the body's immune system attack the cancer, and may interfere with the ability of tumor
cells to grow and spread. ASTX727 consists of the combination of decitabine and cedazuridine.
Cedazuridine is in a class of medications called cytidine deaminase inhibitors. It prevents
the breakdown of decitabine, making it more available in the body so that decitabine will
have a greater effect. Decitabine is in a class of medications called hypomethylation agents.
It works by helping the bone marrow produce normal blood cells and by killing abnormal cells
in the bone marrow. Giving nivolumab in combination with ASTX727 may shrink and stabilize
cancer.