Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer
Status:
Recruiting
Trial end date:
2024-09-30
Target enrollment:
Participant gender:
Summary
The purpose of this phase 2 research study is to determine whether a combination of
chemotherapy drugs plus radiation therapy, given before surgery in resectable pancreactic
cancer, can help to increase the chances of surgeons achieving and R0 resection. The
chemotherapy drugs used are gemcitabine and nab-paclitaxel. These drugs are both approved by
the FDA for use in treating adults with pancreatic adenocarcinoma. The investigational
portion of this study is providing the chemotherapy drugs and radiation therapy before
surgery. Primary Endpoint, R) resection rate ≥70%. Secondary Endpoints, Disease free
survival, Overall survival , Perioperative mortality and morbidity.