Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate

• Status: Withdrawn
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

A proof of concept clinical trial to assess the synergism of curcumin (CURC) and ursolic acid (UA). Before further testing within formal cancer clinical trials, we must (1) evaluate the bioavailability and safety, (2) confirm the presence of metabolites in the target organ, and (3) validate the appropriate mechanism of effect

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center at San Antonio
• Treatments: Curcumin; Ursolic acid

Criteria

Inclusion Criteria:

• Have proven diagnosis of prostate cancer with Gleason Group 3 or lower and planning to undergo radical prostatectomy

• Be able to give informed consent

• Be age 18 or older

• Able to stop supplements

Exclusion Criteria:

• Unable to give informed consent

• Age < 18

• High-risk prostate cancer or suspected metastasis

• Unable to swallow pills

• Unable to stop supplements