Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
This study aims to address the following questions on the effects of testosterone therapy in
men with coronary ischaemia:
- Does the anti-anginal effect persist long term? Many of the published studies are acute
single dose trials and none of the chronic studies have assessed patients formally
beyond a few months. The investigators' earlier studies were limited to 3 months.
- Does testosterone therapy in men affect the levels of measurable atheroma? There is
currently no in-vivo human evidence that androgen therapy inhibits or reduces levels of
atheroma, although there is abundant evidence in animals to suggest a potential
improvement.
This study addresses the two issues and would be of one-year duration but would be the
longest trial of testosterone therapy in men with cardiovascular disease. The primary
endpoint is the change in time to ST- segment depression of > 1mm during exercise testing.