Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

• Status: Completed
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Francisco
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Doxycycline; Minocycline; Tetracycline

Criteria

Inclusion Criteria:

• Giant aneurysms or brain arteriovenous malformations (BAVM)

• Female patients of child bearing age using effective birth control, males

• Creatinine no greater than 2.0 mg/dl

• ALT no greater than 2 times upper limit of control

Exclusion Criteria:

• Unstable medical illness

• Contraindications to Tetracycline

• History of vestibular disease, (except benign positional vertigo)

• Prior tetracycline use within 2 mos of baseline visit.

• History of noncompliance with treatment or other protocols

• History of systemic lupus

• Patients not eligible for MRI