Thalidomide and Temozolomide in Relapsed or Progressive CNS Disease or Neuroblastoma
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Thalidomide may stop the growth of tumor cells by stopping blood flow to the
tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop tumor
cells from dividing so they stop growing or die. Combining thalidomide with temozolomide may
kill more tumor cells.
PURPOSE: This phase II trial is studying the effectiveness of combining thalidomide with
temozolomide in treating young patients who have relapsed or progressive brain tumors or
recurrent neuroblastoma.
Phase:
Phase 2
Details
Lead Sponsor:
Dana-Farber Cancer Institute
Collaborators:
Boston Children's Hospital Boston Children’s Hospital Celgene Corporation National Cancer Institute (NCI)