The ALA, DHA and EPA Esters in the Prevention of Cardiovascular Diseases.
Status:
Enrolling by invitation
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
Essential polyunsaturated fatty acids (EFAs) have a significant impact on human health, even
before birth. Their supplementation is recommended at all ages, especially in people with
cardiolovascular risks. The most valuable proven action of EFAs is the improvement of the
lipid profile (including increase in HDL, the so-called "good cholesterol" and lowering LDL,
the so-called "bad cholesterol"), preventing the development of atherosclerosis, strokes and
heart attacks.
We distinguish three fractions of EFAs: EPA, DHA and ALA. The best known are EPA and DHA, but
in recent years the interest in ALA fraction has increased, as it is the only fraction that
has pronounced anti-inflammatory properties, but also only ALA is not produced by the human
body and must be supplied with food.
We believe that the supplementation of the ALA fraction is as important as the
supplementation of the well-known and recommended EPA and DHA fractions, moreover it also
brings unique benefits. The aim of the study is to demonstrate the benefits of EFAs in the
prevention of cardiovascular diseases in the group of adults. In the project, we also want to
compare the benefits of supplementing various fractions.
Each volunteer will be randomly assigned to one of 4 groups. Group No. 1 will be a group
without the supplementation of essential fatty acids (EFAs), group No. 2 will receive
supplementation with pure ALA fraction, group No. 3 will receive supplementation with EPA and
DHA fractions, and group No. 4 will receive supplementation with all fractions, i.e. ALA, EPA
and DHA. All persons from groups 1-4 will be examined three times: at the beginning, after
three months and after six months (at the end of the project). The tests will include: blood
pressure measurements, non-invasive measurements of body mass and composition, and laboratory
tests: CRP, fasting glucose, lipid profile, and blood count.
Both preparations for acid supplementation and tests are completely free for participants.
Participation in the study is voluntary and is not associated with any health risk.