The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

We hypothesize that simvastatin in combination with ICS might have synergistic anti-inflammatory effects on airway inflammation in asthmatic patients

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Anti-Inflammatory Agents; Simvastatin

Criteria

Inclusion Criteria:

• He or she has FEV1 > 60% of predicted

• He or she requires less than 1000 mcg daily of beclomethasone or equivalent

Exclusion Criteria:

• He or she had previous history of renal disease or serum creatinine more than 2 mg/dL

• He or she had previous history of liver disease

• She is pregnant or during lactation

• He or she has already received statins or is allergic to statins or has developed myositis.

• He or she has an asthma exacerbation and requires treatment with oral corticosteroids during the 3 months prior to the commencement of study entry.