The Anabolic Effect of Testosterone on Pelvic Floor Muscles

• Status: Not yet recruiting
• Trial end date: 2026-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Stress urinary incontinence is the most common female pelvic floor disorder encountered in clinical practice with significant negative impact on quality of life. The prevalence of urinary incontinence increases with aging, and weakness of the pelvic floor muscles contributes to the development of stress urinary incontinence. Given that androgen receptors are expressed throughout the pelvic floor, the anabolic effects of androgens on pelvic floor muscles may provide a therapeutic option in women with stress urinary incontinence. The investigators are conducting a randomized, double-blind, placebo-controlled proof-of-concept trial in older postmenopausal women with stress urinary incontinence to assess whether testosterone therapy can increase pelvic floor muscles and improve urinary function.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Methyltestosterone; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate

Criteria

Inclusion Criteria:

• Women, age 60 years and older.

• Medically documented pure stress urinary incontinence on physical exam or urodynamic testing.

• Normal mammogram within the last 12 months

• Endometrial thickness of ≤4 mm in women with an intact uterus assessed by endometrial ultrasound.

• Ability and willingness to provide informed consent.

Exclusion Criteria:

• • Medically documented urge or mixed urinary incontinence (stress and urge) on physical exam or urodynamic testing.

• Participating in pelvic floor muscle training (PFMT) therapy currently or in the past 3 months

• Previous pelvic surgery (i.e., hysterectomy, pelvic organ prolapse repair, mid-urethral sling placement, injection of urethral bulking agents) or radiation treatment to the pelvis.

• History of ≥ Grade 3 pelvic organ prolapse

• Neurologic disorder causing UI or bladder dysfunction (i.e., multiple sclerosis, Parkinson's disease, stroke, cerebral palsy, spinal cord injury)

• Current urinary tract infection

• History of breast or endometrial cancer

• Use of systemic estrogen therapy in the past 3 months

• Baseline hematocrit >48%, serum creatinine >2.5 mg/dL; HbA1c >8.0%; BMI >40 kg/m2

• Uncontrolled hypertension defined as an average of two blood pressure readings of greater than 160/100.

• Subjects who are on insulin therapy will be excluded.

• Uncontrolled congestive heart failure

• Myocardial infarction, acute coronary syndrome, revascularization surgery or stroke within 6 months

• History of pulmonary embolism, deep vein thrombosis or a genetic thromboembolic disorder

• History of bipolar disorder, schizophrenia or untreated major depression

• Presence of metallic implants (pacemakers, aneurysm clips, etc.) that preclude the patient from undergoing MRI