The Anti-fungal Effect of Miconazol Versus Miconazol-Loaded Chitosan Nanoparticles

• Status: Completed
• Trial end date: 2023-07-27
• Target enrollment: 0
• Participant gender: All

Summary

Objective: this study aimed to evaluate the therapeutic effects of topical application of miconazole and miconazole-loaded chitosan nanoparticles in treatment diabetic patients with oral candidiasis.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yasmine gamil
• Treatments: Chitosan

Criteria

Inclusion Criteria:

1. uncontrolled diabetes patients with oral candidiasis and their uncontrolled diabetes were confirmed by doing glycated hemoglobin test and their range is >7.0%,

2. age ranged from 30-65 years

3. patients were willing to participate in this study

Exclusion Criteria:

1. immunocompromised and patients with systemic diseases that can cause muscle weakness as Parkinson's disease, or others that can limit their cognitive functioning such as dementia

2. pregnant

3. nursing women

4. smokers

5. alcoholic patients were also excluded from the study.

6. should not have a history of use of any drugs that can cause hyposalivation or broad spectrum antibiotics, within the last month.