The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease

• Status: Completed
• Trial end date: 2017-03-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if the prophylactic use of azithromycin will reduce the total number of days when unscheduled treatment is given outside of the home in a clinic, urgent care, emergency room or hospital setting between the respiratory illness season months (October 1-March 31) and subsequent 2 month follow-up (April and May)

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Treatments: Anti-Inflammatory Agents; Azithromycin

Criteria

Inclusion Criteria:

• children with a diagnosis of chronic lung disease (CLD) secondary to bronchopulmonary dysplasia (BPD) as defined by ATS.

• children who receive primary care at High Risk Infant Clinic or High Risk Children's Clinic

Exclusion Criteria:

• Children with Cystic Fibrosis or bronchiectasis

• Children with cardiac arrhythmias

• Children with cyanotic heart disease

• Children with colitis

• Children with a known Macrolide allergy

• Children taking medications known to interact with macrolides

• Children with short bowel syndrome

• Children with kidney or liver failure