The Application of Docozine Combined With Sufentanil for Awake Tracheal Intubation
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Mortality associated with difficult airway in anesthesia is up to 30%. So, it is urgent to
find a safe and effective method for intubation. Awake tracheal intubation which is used to
retain spontaneous breathing is one of the important measures to ensure the safety of the
patients with difficult airway in anesthesia.
Sufentanil is used to provide good analgesia and can effectively inhibit the reaction of
awake tracheal intubation, however, the outstanding problem is serious respiratory depression
after intravenous sufentanil injection. Few study showed that dezocine is a kappa opioid
antagonist related to mild respiratory depression and can prevents sufentanil-induced cough
during general anesthesia induction.It is necessary to carry out large-scale, multi-center,
randomized, controlled clinical study to determine whether dezocine prevents
sufentanil-induced respiratory depression and whether dezocine combined sufentanil is a safe
and effective method for awake tracheal intubation.
Phase:
Phase 4
Details
Lead Sponsor:
The First Affiliated Hospital of Anhui Medical University