The Application of Glucose CEST MR Imaging in Brain Tumor

• Status: Recruiting
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Recently, natural D-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using D-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. Our study try to evaluate the feasibility of dynamic glucose enhanced(DGE) magnetic resonance imaging（MRI）in brain tumor, which based on D-glucose weighted chemical exchange saturation transfer (gluceoCEST).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhujiang Hospital

Criteria

Inclusion Criteria:

• Patient must have a brain mass consistent with a primary brain tumor or metastatic brain tumor

• able to give consent and willingness to participate in this study.

Exclusion Criteria:

• presence of any ferromagnetic implant (cardiac pacemakers, aneurysm clip, etc.)

• pregnancy

• claustrophobia or anxiety disorder

• history of vertigo

• persons with diabetes mellitus (self-report or HbA1C >= 6.5%)

• Sickle cell disease

• persons taking prescription medicine for hypertension

• blood iron deficiency (Hb concentration < 11 g/dL or Hct < 32%)

• If volunteering for MRI: history of kidney disease and/or eGFR < 60.

• Middle-ear disorder

• double vision

• Seizure disorder

• Multiple myeloma

• Solid organ transplant

• History of severe hepatic disease/liver transplant/pending liver transplant