The Arterial Measurement of the Blood Flow Volume After Iloprost Stimulation
Status:
Unknown status
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
A prospective case-control study was performed to investigate the effect of iloprost on the
intraoperative flow volume in diabetic and non-diabetic patients as well as the effect of
peripheral neuropathy in patients with peripheral arterial occlusive disease (PAOD)
undergoing arterial reconstruction (primary endpoint).
100 patients undergoing femoral artery reconstruction or femorodistal bypass surgery were
included. Prior to surgery, peripheral nerve conduction velocity was measured. Blood flow
volume at the common femoral artery was assessed using a Doppler flowmeter (Sono TT FlowLab;
) before reconstruction, prior to the intraarterial application of 3000ng of iloprost and 5
and 10 minutes afterwards. Peripheral resistance units (PRU) were calculated as a function of
mean systemic arterial pressure (MAP) and flow volume (VF): PRU = MAP (mmHg) / VF (ml/min).