The Association Between Hyponatremia and Osteoporosis in Patients With Epilepsy.

• Status: Completed
• Trial end date: 2018-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study investigates the association between normalization of serum sodium levels and bone markers in patients with epilepsy and chronic hyponatremia.

The study is a randomized, single blinded, placebo controlled study where participants will be randomized to either treatment with salt tablets or placebo tablets through 4 months. At the beginning and end of the 4 months bone markers will be measured.

The investigators null-hypothesis is that there will be no difference in bone markers before or after the intervention.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark

Criteria

Inclusion Criteria:

• Epilepsy requiring treatment for at least 2 years

• Known hyponatremia (2 subsequent s-sodium values < 136 mmol/l)

• Age 18-80 years

• Danish speaking

• Signed form of prior consent

Exclusion Criteria:

• Pregnancy and breastfeeding

• Known osteoporosis. DXA scan < -2.5 T-score. Z-score is used for patients 50 years or younger.

• Undergoing treatment for osteoporosis

• Undergoing treatment with salt tablets

• Known SIADH

• Severe concomitant disease such as cancer or ischemic heart disease

• Alcohol, drug or substance abuse