This study is being completed to better understand who benefits from different chronic pain
treatments and how these treatments work.
This study will include a four week run-in period for all cLBP participants. After completing
the PainGuide (online or smart phone accessible website) run-in period, participants will be
assessed using either the light or light plus deep phenotyping assessment battery and those
who minimal or modest improvement in their pain (based on PGIC) will be randomized to one of
four 8-week treatments (mindfulness-based stress reduction (MBSR), physical therapy (PT) and
exercise, acupressure self-management, or duloxetine).
In addition, participants will complete study visits including physical exams, complete
surveys, provide samples (blood,saliva, etc.), wear an electronic wrist device at certain
times, and have Magnetic resonance imaging (MRIs) during the study.
Following one of the 4 treatments (8 weeks) if participants have a certain level of pain
(that meets eligibility for more treatment) they will be then randomized to complete one of
the 3 treatments that was not already assigned to them.
The study hypothesizes the following:
that this interventional response phenotyping can identify individuals with different
underlying mechanisms for their pain who thus respond differentially to evidence-based
interventions for chronic lower back pain (cLBP).
Phase:
Phase 4
Details
Lead Sponsor:
University of Michigan
Collaborator:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)