The Benefit and Harm of Fever Suppression by Antipyretics in Influenza

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the potential benefits and risks of antipyretics use in naturally occurring influenza virus infections in humans.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Hong Kong
• Treatments: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Ibuprofen

Criteria

Inclusion Criteria:

• Adults aged between 18-30

• Presenting with symptoms of acute URTI (at least two among the following symptoms:

body temperature ≥37.8°C, cough, rhinorrhea, sore throat, headache, myalgia/arthralgia) within 48 hours of illness onset

• being tested positive with a QuickVue rapid influenza test

Exclusion Criteria:

• Allergic to paracetamol or any other antipyretics

• Have any underlying immunocompromized condition or be receiving immunosuppressive agents.

• Have any history of chronic liver disease, or any active lung, heart or renal diseases requiring regular medication.