The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children
Status:
Recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
The goal of this interventional study is to learn about the efficacy and safety of first line
anti epileptic drugs (AEDs) as substitution therapy for children who are resistant to
second-line AEDs. The main question to answer it aims are :
how much the difference proportion of responders (responders are children who achieve the
decrease of seizure frequencies by 50%) how much time it is needed to achieve the decrease of
seizure frequencies by 50% The patients who are eligible for the study and have given their
consent, will be enrolled, divided into 2 groups, the control and intervention.
The participant should follow the 14 weeks of intervention that consists of 6 phases :
baseline, initial dose, titration dose, maintenance dose, tapering-off dose, and new
combination maintenance dose.